Mosquitoes are not very popular with human beings. They suck your blood and can cause infections. Many ways have been devised to limit their attacks. Female mosquitoes are efficient carriers of deadly diseases such as malaria, dengue and yellow fever, resulting each year in several million deaths and hundreds of millions of cases. To find human hosts to bite and spread disease, these mosquitoes use exhaled carbon dioxide as a vital cue. A disruption of the carbon dioxide detection machinery of mosquitoes, which would help control the spread of diseases they transmit, has therefore been a long sought-after goal. Anandasankar Ray, an assistant professor of entomology at the University of California, Riverside, and colleagues report that they have identified in the lab and in semi-field trials in Africa three classes of volatile odor molecules that can severely impair, if not completely disrupt, the mosquitoes’ carbon dioxide detection machinery.