There may be far fewer galaxies further out in the Universe then might be expected, suggests a new study based on simulations conducted using the Blue Waters supercomputer at the National Center for Supercomputing Applications, with resulting data transferred to SDSC Cloud at the San Diego Supercomputer Center at the University of California, San Diego, for future analysis. The study, published this week in the Astrophysical Journal Letters, shows the first results from the Renaissance Simulations, a suite of extremely high-resolution adaptive mesh refinement (AMR) calculations of high redshift galaxy formation. Moreover, these simulations show hundreds of well-resolved galaxies, allowing researchers to make several novel and verifiable predictions ahead of the October 2018 launch of the James Webb Space Telescope (JWST), a new space observatory that succeeds the Hubble Space Telescope.